Table 1. Summary of the treatment and overall survival in the cervical cancer patients with brain metastases.
| Study | Age (yr) | Histology | Site | Treatment | Systemic disease control | Outcome* |
|---|---|---|---|---|---|---|
| Kumar et al. (1992) [104] | - | - | Solitary metastasis | Surgery+WBRT | - | 7 mo |
| Kumar et al. (1992) [104] | - | - | Multiple brain metastases | WBRT | - | 2 mo |
| Robinson et al. (1997) [105] | 68 | Moderately differentiated squamous cell carcinoma | An isolated subtentorial cerebellar mass | Surgery+WBRT (whole brain 30 Gy with 10 Gy subtentorial boost) | Yes | 6 yr |
| Cormio et al. (1999) [106] | 51 | - | A solitary right frontal lobe lesion | Surgery+chemotherapy (3 cycles of cisplatin) | Yes | 11 mo |
| Omari-Alaoui et al. (2003) [107] | 48 | Undifferentiated invasive squamous carcinoma | Isolated left cerebellum | Surgery+WBRT (whole brain 30 Gy with boost in posterior fosse of 15 Gy) | Yes | 8 mo |
| Omari-Alaoui et al. (2003) [107] | 67 | Poor differentiated invasive squamous carcinoma | Three space occupying lesions in the posterior fosse | WBRT (30 Gy) | Yes | 2 mo |
| Tajran et al. (2003) [108] | 59 | Moderately differentiated papillary adenocarcinoma | A right temporal-parietal lobe lesion | WBRT (45 Gy) | Yes | 4.5 mo |
| Wuntkal et al. (2004) [109] | 44 | Poorly differentiated adenosquamous carcinoma | Carcinomatous meningitis | Radiation therapy+chemotherapy (intrathecal methotrexate parenteral dexamethasone and 5 cycles of systemic carboplatin) | No | 5 mo |
| Amita et al. (2005) [110] | 54 | Poorly differentiated squamous cell carcinoma | Isolated left parieto-occipital lobe metastasis | Surgery+WBRT (whole brain 30 Gy with boost in posterior fosse of 10 Gy) | Yes | 6 mo |
| Cordeiro et al. (2006) [111] | 31 | Poorly differentiated carcinoma | A left occipital lesion | Surgery+WBRT | Yes | 5 yr |
| Cordeiro et al. (2006) [111] | 31 | Poorly differentiated adenosquamous carcinoma | A right hemispheric cerebellar lesion | WBRT | No | 1 mo |
| Brown et al.(2007) [112] | 60 | - | A large right occipital CNS metastasis | SRS (16 Gy)+chemotherapy (6 cycles of paclitaxel [175 mg/m2] and carboplatin [AUC, 5]) | Yes | 5 mo |
| Park et al. (2010) [113] | 48 | Moderately differentiated squamous cell carcinoma | Multiple | WBRT (30 Gy)+steroids | Yes | 6 mo |
| Marongiu et al. (2012) [114] | 48 | Poorly differentiated squamous cell carcinoma | A left parietal lesion | WBRT+chemotherapy | No | 11 mo |
| Marongiu et al. (2012) [114] | 34 | Small cell neuroendocrine carcinoma | A left postrolandic lesion | Surgery | Yes | 11 mo |
| Erdis (2014) [99] | 67 | Squamous cell carcinoma | Solitary metastasis | WBRT (30 Gy) | No | Long-term disease-free survival |
AUC, area under the curve; CNS, central nervous system; WBRT, whole brain radiotherapy; SRS, stereotactic radiotherapy.
*Outcome, from the date of diagnosis of brain metastasis to the date of death.