Figure 1.

The expression of CYC1 is strongly upregulated in human malignant breast tumor tissues and is negatively correlated with patient survival. Kaplan-Meier curve was got from an integrated database and an online tool (http://www.kmplot.com/), showing the good prognostic effect of CYC1 upregulation correlated with a bad OS in breast cancer patients (n = 3554; use earlier release of the database: 2014 version), p < 0.01 (a). Low CYC1 expression in breast benign tumor (case 10, the upper row) and high CYC1 expression in malignant breast tumor (case 26, the lower row), evaluated by immunohistochemical analysis (b). IHC score of each patient was plotted as an individual dot in the chart. p < 0.01 (c).