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. Author manuscript; available in PMC: 2017 May 10.
Published in final edited form as: Cell Metab. 2016 May 10;23(5):785–796. doi: 10.1016/j.cmet.2016.04.004

Figure 1.

Figure 1

Transferring Mitochondria for multiple applications. Mitochondria are double-membrane bound organelles that contain their own genome (mtDNA), which is organized into nucleoprotein structures, called nucleoids, attached to the inner membrane facing the mitochondrial matrix. Transfer of exogenous mitochondria into cells that contain or lack (ρ0 cells) mtDNA could improve our understanding of ETC function, metabolism, and the interaction between the mitochondrial and nuclear genomes. Mitochondrial transfer also may hold potential for treating diseases of dysfunctional mitochondria caused by mutations in mtDNA.