Figure 3.

Blockade of mGluR2/3 does not alter locomotive activity or anxiety. (a) Freezing responses to fear conditioning for the groups in which LY341495 (or vehicle) was microinfused into the LA (open circle, vehicle-infused controls, n=7; filled circle, LY341495-infused group, n=6). (b) Schematic illustration of cannula tip placements for the experiments shown in a and c. (c) No significant changes in locomotive activity by microinfusion of LY341495 24 h after conditioning (vehicle-infused controls, n=7; LY341495-infused group, n=6). Locomotive activity was assessed 15 min after the infusion. Left, total distance travelled and velocity in the two groups. Right, the time in the center of open field and the number of center entries in the two groups. (d) Freezing responses to fear conditioning and subsequent extinction for the groups in which LY341495 (or vehicle) was microinfused into the LA (open circle, vehicle-infused controls, n=6; filled circle, LY341495-infused group, n=6). (e) Schematic illustration of cannula tip placements for the experiments shown in d and f. (f) No significant changes in locomotive activity by microinfusion of LY341495 24 h after conditioning (vehicle-infused group, n=6; LY341495-infused group, n=6). Locomotive activity was assessed 24 h after extinction training. Left, total distance and velocity measured for locomotion assessment. Left, total distance travelled and velocity in the two groups. Right, the time in the center of the open field and the number of center entries in the two groups. Error bars indicate SEM.