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. 2015 Jun 17;40(13):2916–2928. doi: 10.1038/npp.2015.145

Figure 4.

Figure 4

Microinfusion of LY341495 into the LA attenuates the extinction-induced weakening of C-LA synaptic efficacy, but has no significant effect at T-LA synapses or inhibitory synapses in principal neurons of the LA. (a) Input–output curves for EPSCs at C-LA synapses in vehicle- and LY341495-infused groups (vehicle-infused group, n=9 from eight rats; LY341495-infused group, n=10 from eight rats). Representative traces are an average of five consecutive responses with input stimulations of 35 μA (scale bars, 10 ms and 100 pA). (b) The slope of the input–output curve in the LY341495 group was significantly larger than that in vehicle-infused controls. *P<0.05. (c) Schematic illustration showing cannula tip placement for the electrophysiological experiments shown in this figure and Figure 5. Left, cannula tip placements for vehicle-infused group (open circle). Right, cannula tip placements for the LY341495-infused group (filled circle). (d) Input–output curves for EPSCs at T-LA synapses in vehicle- and LY341495-infused groups (vehicle-infused group, n=9 from eight rats; LY341495-infused group, n=9 from seven rats). Representative traces are an average of five consecutive responses with input stimulations of 35 μA (scale bars, 10 ms and 200 pA). (e) The slope of the input–output curve at T-LA synapses in the LY341495 did not differ significantly from that of vehicle-infused controls. (f) The frequency and amplitude of mIPSC in LA principal neurons from vehicle- and LY341495-infused groups (vehicle-infused group, n=8 from five rats; LY341495-infused group, n=8 from five rats; scale bars, 1 s and 50 pA).