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. 2015 Jun 17;40(13):2916–2928. doi: 10.1038/npp.2015.145

Figure 5.

Figure 5

Fear conditioning reduces and extinction training enhances PPR. Microinfusion of LY341495 into the LA blocks the extinction-induced enhancement in PPR at C-LA synapses but not T-LA synapses. (a) The behavioral procedure for the experiments shown in b-c. (b) Freezing responses in the conditioned and extinction groups. A day after extinction training, one set of rats was killed to prepare brain slices, and another set was used to monitor conditioned freezing for the retention test (conditioned group, n=8; extinction group, n=7). (c) PPR of AMPA EPSCs at C-LA synapses in naive controls, conditioned, and extinction groups (naive controls, n=6 from four rats; conditioned group, n=13 from eight rats; extinction group, n=8 from four rats). Representative traces show an average of ten consecutive responses (scale bars, 10 ms and 50 pA). *P<0.05. (d) PPR of AMPA EPSCs at C-LA synapses in vehicle- and LY341495-infused groups (vehicle-infused group, n=8 from seven rats; LY341495-infused group, n=9 from six rats). **P<0.01. (e) PPR of AMPA EPSCs at T-LA synapses in vehicle- and LY341495-infused groups (vehicle-infused group, n=6 from four rats; LY341495-infused group, n=10 from eight rats). Representative traces in d and e are an average of 8–10 consecutive responses (scale bars, 10 ms and 20 pA).