Figure 5.

ZCZ011 partially reversed mechanical allodynia in the carrageenan model of inflammatory pain. The CB₁ receptor antagonist rimonabant (SR141716A, SR1; 3 mg/kg; (a), but not the CB₂ receptor antagonist SR144528 (SR2; 3 mg/kg; b) blocked the anti-allodynic effects of ZCZ011. Results presented as mean±SEM (n=9–12 mice per group). ZCZ011 (40 mg/kg, i.p.) did not attenuate carrageenan-induced paw edema (c and d). Values represent mean±SEM, n=8 mice per group.*P<0.05, ***P<0.001, ^###P<0.001 vs vehicle; ^$$P<0.01, ^$$$P<0.001 vs contralateral paw.