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. 2015 Jul 1;40(13):2993–3005. doi: 10.1038/npp.2015.155

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Copyright © 2015 American College of Neuropsychopharmacology

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Global features of CpGs associated with cross-generational effects of THC exposure. (a) Density of CpGs plotted against the estimated mean methylation values between 0 and 100% (calculated across all THC and VEH animals) from both the background CpG list (black; n=567,306), and the hypermethylated (red) and hypomethylated (blue) DMRs; CpGs within DMRs have higher methylation levels on average. (b) Density of significant CpGs (q<0.01) from hyper- and hypomethylated DMRs (n=3,758) plotted against the difference in mean methylation values observed between THC and VEH groups, with hypermethylated changes (between-group difference>0%) shown in red, and hypomethylated changes shown in blue. DMRs, differentially methylated regions; THC, tetrahydrocannabinol; VEH, control vehicle