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. 2015 Jul 1;40(13):2993–3005. doi: 10.1038/npp.2015.155

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Copyright © 2015 American College of Neuropsychopharmacology

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Localization of CpGs with respect to exon/intron, promoter/TSS, and CpG island annotations in the rn4 genome. (a) The proportions of CpGs in hyper- and hypomethylated DMR (‘Hyper', ‘Hypo' n=5,611) and background sets (‘All' n=567,306) overlapping Refseq gene (left panel) and CpG island annotations (right panel). (b) Comparison of genomic distances (bp) from Refseq gene TSSs of promoter-associated CpGs within DMRs (n=612) and the background set (n=235 524), represented by red/blue and black lines; DMR-CpGs were preferentially located downstream of TSSs.DMR, differentially methylated region; TSS, transcription start site.