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. 2015 Jul 8;40(13):3044–3052. doi: 10.1038/npp.2015.161

Figure 4.

Figure 4

Pre-exposing animals to the retrieval context or auditory cue by themselves do prevent memory reconsolidation following retrieval. (a) Rats were trained to 100% reinforcement auditory fear conditioning with pre-exposure to the retrieval context or the auditory cue in Context C the day before training. All animals received a retrieval in Context B on day 3 and amygdala tissue collected 120 min later (n=11–12 per group). (b) Pre-exposure to the retrieval context or the CS in Context C by themselves decreased GluR1 and GluR2 expression in the amygdala after retrieval without altering β-actin expression (c). (d) Pre-exposing animals to the retrieval context, but not the auditory cue in Context C, prevented increases in GluR1 expression in the hippocampus following retrieval without altering GluR2 or b-actin expression (e). *P<0.05 from no retrieval. #P=0.07 from no retrieval.