Figure 5.

Pre-exposing animals to the retrieval conditions prevents memory impairments from post-retrieval protein synthesis inhibition in the amygdala. (a) Rats were trained with 100% contingent auditory fear conditioning with or without ‘retrieval pre-exposure' the day before training. On the day after training, animals received a brief retrieval followed by infusions of vehicle or the protein synthesis inhibitor anisomycin (ANI) into the amygdala. All groups were tested for memory with the auditory cue 24 h after the retrieval/infusion procedure (n=7–8 per group). (b) There were no differences between groups during retrieval. (c) The group that received ANI without retrieval pre-exposure had significant impairments in memory for the auditory cue relative to controls, whereas the groups receiving ANI with retrieval pre-exposure performed similar to controls throughout most of the test session. *P<0.05 from ACSF.