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. 2015 May 13;40(12):2696–2704. doi: 10.1038/npp.2015.116

Figure 3.

Figure 3

Changes in cocaine-induced DA overflow in the NAc over self-administration. (a) Rats received a single non-contingent cocaine infusion (1.2 mg/kg, i.v.) early (Week 2, solid lines) and again late during self-administration (Week 7, dashed lines). Cocaine-induced DA overflow was significantly attenuated in CP rats during Week 7 compared with their earlier response (*p<0.05) and the late responses of ABST and PP rats (#p<0.05 compared with late CP). Data are repeated measures from 11 ABST rats (5 female, 6 male, white circles), 5 PP rats (2 female, 3 male, gray circles) and 9 CP rats (5 female, 4 male, black circles). Basal DA values in pg per 10 min sample were not different between groups at either time point: ABST rats (early: 7.2±1.9, late: 11.4±2.7), PP rats (early: 6.3±1.6, late: 4.4±1.3), and CP rats (early: 9.3±1.2, late: 11.9±3.2). (b) Both CP males and females displayed attenuated cocaine-induced DA overflow during Week 7 compared with Week 2 (*p<0.05). Vertical lines represent SEM. ABST, abstaining; CP, cocaine preferring; DA, dopamine; NAc, nucleus accumbens; PP, pellet preferring.