Table 2. Neuroanatomical Regions Showing Significant fALFF–Cognition Slopes across Healthy Control and Schizophrenia Groups.
| CMINDS test | Cluster neuroanatomy | FWE cluster-corrected p-value | Number of 3 mm3 voxels | Peak MNI coordinate (x, y, z) |
|---|---|---|---|---|
| Regions showing fALFF–cognition slope differences between groups | ||||
| CPT-IP d' | Dorsal anterior cingulate cortex/supplementary motor area (BA 8, 24, 32) | P=0.04 | 124 | 3x 15y, 33z |
| CPT-IP d' | Right dorsolateral/superior frontal cortex (BA 6, 8, 9, 46) | P<0.001 | 322 | 45x, 0y, 57z |
| CPT-IP d' | Bilateral posterior lateral parietal, medial parietal, and posterior cingulate cortex, extending into temporal and occipital cortex (BA 5, 7, 19, 30, 31, 39, 40) | P<0.001 | 3710 | 6x, −69y, 51z |
| Regions showing fALFF–cognition slopes common to both groups | ||||
| CPT-IP d' | Left superior frontal cortex (BA 6, 8) | P=0.02 | 134 | −30x, 15y, 60z |
| CPT-IP d' | Left temporal cortex | P=0.02 | 136 | −33x, −39y, 3z |
| CPT-IP d' | Right temporal cortex | P=0.03 | 128 | 21x, −42y, 24z |
| Spatial Memory Span | Medial prefrontal cortex, extending to bilateral dorsolateral prefrontal cortex (BA 6, 8, 9, 10, 32) | P<0.001 | 1811 | 12x, 42y, 51z |
| Spatial Memory Span | Left temporoparietal junction/inferior parietal lobule (BA 39, 40) | P=0.002 | 214 | −48x, −66y, 42z |
| Spatial Memory Span | Right temporoparietal junction/inferior parietal lobule (BA 39, 40) | P<0.001 | 298 | 51x, −42y, 30z |
Abbreviation: BA, Brodmann area. Common slopes and slope differences between groups are listed above. Cluster-corrected p-values are family-wise error (FWE) corrected, at a height threshold of p<0.01.