Table 1.

MPS-specific physical symptom scale

Feature	Score	Description
Skeletal/orthopedic	0	No orthopedic symptom
	1	1–2 symptoms
	2	3–4 symptoms
	3	5–6 symptoms or cord compression
Skeletal/orthopedic symptoms include limited range of motion, kyphosis, scoliosis, hip dysplasia, knock knee, and high arch foot
Vision	0	No visual impairment or symptom
	1	Mild corneal clouding or glaucoma or cataract
	2	Moderate corneal clouding or both glaucoma and cataract
	3	Severe corneal clouding or retinal degeneration
Hearing	0	None
	1	Mild hearing loss
	2	Moderate hearing loss
	3	Severe hearing loss
Cardiorespiratory	0	None
	1	1–2 cardiac or respiratory symptoms
	2	3–4 symptoms or presence of sleep apnea
	3	5–6 symptoms or history of cardiac surgery
Cardiac and respiratory symptoms include murmur, hypertension, valve disease, cardiac surgery, chronic nasal discharge/obstruction, tonsils/adenoids, respiratory infection/reactive airway disease, and sleep apnea
Hydrocephalus	0	Absent
	1	Hydrocephalus without shunt
	2	Hydrocephalus with shunt
	3	Revision of shunt
Number of surgeries	0	No surgery
	1	Less than 4 surgeries
	2	4 to 8 surgeries
	3	More than 8 surgeries
Total score = 0–18