Table 2.

Frequently used drugs during childhood cancer treatment that are implicated in AP etiology

Drug group	Drug	Classification by Trivedi et al. 8	Classification by Badalov et al. 29	Other references
Chemotherapeutics	L ‐ Asparaginase	Class I	Class II	11, 12, 13, 14, 15, 17, 18, 19, 20, 21
	Mercaptopurine	Class I	Class Ib	22, 23, 24
	Cytosine arabinoside	Class I	Class Ib	25, 26, 27, 28
	Ifosfamide	/	Class Ib	30, 31
	Cisplatin	Class II	/	32
	Doxorubicin	Class III	/
	Methotrexate	Class III	/	33
Immunomodulators	Tacrolimus	Class III	Class IV	47, 48
	Cyclosporine	Class III	Class III	49
Steroids	Steroids	Class I		34, 35
	Dexamethasone		Class Ib	34
	Prednisone		Implicated as causing AP	34
Antimicrobial drugs	TMP/SMX	Class I	Class Ia	11, 36, 37
	Erythromycin	Class II	Class II
	Tetracyclines	Class I	Class Ia
	Cidofovir	Class III	/
	Ganciclovir	Class III	/
	Ribavirine	Class III	/
	Voriconazole	Class III	/
Other drugs	Propofol	Class III	Class II	38, 39, 40
	Omeprazole	Class III	Class Ib	41, 42
	Paracetamol	/	/	43, 44
	Furosemide	Class I	Class Ib

TMP/SMX, trimethoprim/sulfomethoxazole; AP, acute pancreatitis.