Table 2.
Percentages, odds ratios, and 95% confidence intervals (CI) of receiving adjuvant chemotherapy for stage III colon cancer patients based on different comorbidity groupings
| Variables | N (% Received chemotherapy)N = 3180 (64.3%) | Unadjusted Odds Ratio (95% CI) | Adjusted Odds Ratio (95% CI) | ||
|---|---|---|---|---|---|
| Model I | Model II | Model III | |||
| Comorbidity type | |||||
| No comorbidity recorded | 956 (62.7) | 0.76 (0.64–0.91) | 0.86 (0.68–1.08) | – | – |
| Non‐Charlson comorbidity | 1256 (68.9) | ref | ref | – | – |
| Charlson comorbidity | 968 (60.1) | 0.68 (0.57–0.81) | 0.89 (0.73–1.09) | – | – |
| Number of Charlson Comorbidity | |||||
| No comorbidity recorded | 956 (62.7) | 0.76 (0.64–0.91) | – | 0.86 (0.68–1.08) | – |
| Non‐Charlson comorbidity | 1256 (68.9) | ref | – | ref | – |
| 1 Charlson comorbidity | 674 (64.2) | 0.81 (0.67–0.99) | – | 1.01 (0.80–1.26) | – |
| 2 + Charlson comorbidities | 294 (50.7) | 0.46 (0.36–0.60) | – | 0.69 (0.51–0.92) | – |
| Severity of Charlson Comorbidity | – | – | – | – | – |
| No comorbidity recorded | 956 (62.7) | 0.76 (0.64–0.91) | – | – | 0.86 (0.68‐1.08) |
| Non‐Charlson comorbidity | 1256 (68.9) | ref | – | – | ref |
| Mild (weight = 1) | 818 (62.2) | 0.75 (0.62–0.90) | – | – | 0.96 (0.77–1.19) |
| Moderate to severe (weight = 2,3,6) | 150 (48.7) | 0.43 (0.31–0.60) | – | – | 0.62 (0.42–0.91) |
| Age at diagnosis | |||||
| <50 | 350 (86.3) | ref | ref | ref | ref |
| 50–59 | 543 (79.9) | 0.63 (0.44–0.92) | 0.62 (0.42–0.91) | 0.62 (0.42–0.91) | 0.62 (0.42–0.91) |
| 60–69 | 837 (74.8) | 0.47 (0.34–0.66) | 0.46 (0.32–0.66) | 0.47 (0.32–0.67) | 0.46 (0.32–0.67) |
| 70–79 | 766 (64.1) | 0.28 (0.20–0.40) | 0.28 (0.19–0.40) | 0.28 (0.20–0.41) | 0.28 (0.19–0.41) |
| ≥80 | 684 (28.2) | 0.06 (0.04–0.09) | 0.06 (0.04–0.08) | 0.06 (0.04–0.09) | 0.06 (0.04–0.08) |
| Sex | |||||
| Male | 1616 (66.6) | ref | ref | ref | ref |
| Female | 1564 (62.0) | 0.82 (0.71–0.94) | 0.98 (0.83–1.16) | 0.97 (0.82–1.15) | 0.97 (0.82–1.15) |
| Race/ethnicity | |||||
| Non‐hispanic white | 2097 (63.3) | ref | ref | ref | ref |
| Non‐hispanic black | 487 (74.3) | 1.68 (1.34–2.09) | 1.29 (0.99–1.69) | 1.29 (0.98–1.68) | 1.31 (1.00–1.72) |
| Hispanic | 499 (59.7) | 0.86 (0.70–1.05) | 1.01 (0.79–1.30) | 1.01 (0.78–1.30) | 1.02 (0.79–1.31) |
| Non‐hispanic other | 97 (59.8) | 0.86 (0.57–1.31) | 0.74 (0.46–1.20) | 0.73 (0.45–1.18) | 0.73 (0.45–1.18) |
| Health insurance | |||||
| No insurance | 165 (73.3) | 1.04 (0.72–1.49) | 0.81 (0.55–1.21) | 0.81 (0.54–1.20) | 0.81 (0.54–1.20) |
| Private | 1377 (72.6) | ref | ref | ref | ref |
| Medicaid | 345 (57.4) | 0.51 (0.40–0.65) | 0.48 (0.36–0.64) | 0.48 (0.36–0.64) | 0.48 (0.36–0.65) |
| Medicare and other public insurance | 1293 (56.2) | 0.48 (0.41–0.57) | 0.81 (0.66–0.98) | 0.80 (0.66–0.98) | 0.80 (0.66–0.98) |
| Census tract residence | |||||
| 100% Urban | 1843 (60.8) | ref | ref | ref | ref |
| 100% Rural | 280 (67.1) | 1.32 (1.01–1.72) | 1.04 (0.76–1.43) | 1.03 (0.75–1.42) | 1.04 (0.75–1.42) |
| Mixed | 1057 (69.7) | 1.48 (1.26–1.74) | 1.30 (1.06–1.59) | 1.30 (1.06–1.59) | 1.29 (1.05–1.58) |
| Census track poverty | |||||
| Poverty <10% | 1721 (63.7) | ref | ref | ref | ref |
| Poverty 10–20% | 916 (67.5) | 1.18 (1.00–1.40) | 1.12 (0.92–1.36) | 1.11 (0.91–1.35) | 1.12 (0.92–1.36) |
| Poverty > 20% | 543 (61.0) | 0.89 (0.73–1.08) | 0.82 (0.64–1.04) | 0.82 (0.64–1.04) | 0.82 (0.64–1.05) |
| State of residence | |||||
| AK | 34 (70.6) | 2.00 (0.95–4.22) | 1.91 (0.81–4.53) | 1.96 (0.82–4.67) | 1.93 (0.81–4.60) |
| CA | 195 (69.2) | 1.87 (1.35–2.60) | 2.82 (1.87–4.24) | 2.80 (1.86–4.22) | 2.82 (1.87–4.24) |
| CO | 269 (69.9) | 1.93 (1.45–2.58) | 2.78 (2.00–3.87) | 2.79 (2.00–3.89) | 2.81 (2.01–3.91) |
| FL | 564 (58.2) | 1.16 (0.94–1.42) | 1.88 (1.42–2.48) | 1.86 (1.41–2.46) | 1.86 (1.41–2.46) |
| ID | 77 (74.0) | 2.37 (1.40–4.01) | 2.70 (1.50–4.85) | 2.69 (1.50–4.85) | 2.70 (1.50–4.85) |
| LA | 328 (78.7) | 3.07 (2.29–4.10) | 3.57 (2.55–5.00) | 3.55 (2.54–4.97) | 3.51 (2.51–4.91) |
| NC | 546 (74.9) | 2.48 (1.98–3.12) | 3.01 (2.30–3.94) | 3.00 (2.29–3.93) | 3.01 (2.30–3.94) |
| NH | 87 (63.2) | 1.43 (0.91–2.25) | 1.91 (1.13–3.21) | 1.92 (1.14–3.25) | 1.94 (1.15–3.28) |
| RI | 54 (59.3) | 1.21 (0.69–2.11) | 2.17 (1.15–4.10) | 2.19 (1.16–4.14) | 2.21 (1.17–4.17) |
| TX | 1026 (54.6) | ref | ref | ref | ref |
| AJCC stage III | |||||
| IIIA | 364 (59.3) | ref | ref | ref | ref |
| IIIB | 2070 (65.0) | 1.27 (1.01–1.60) | 1.57 (1.21–2.04) | 1.58 (1.21–2.05) | 1.58 (1.21–2.05) |
| IIIC | 746 (64.9) | 1.27 (0.98–1.64) | 1.57 (1.11–2.24) | 1.59 (1.12–2.26) | 1.58 (1.11–2.24) |
| Grade | |||||
| Well/moderately differentiated | 2321 (65.4) | ref | ref | ref | ref |
| Poor/undifferentiated | 859 (61.4) | 0.84 (0.71–0.99) | 0.99 (0.82–1.21) | 0.99 (0.82–1.21) | 1.00 (0.82–1.21) |
| First primary | |||||
| Yes | 2592 (66.0) | ref | ref | ref | ref |
| No | 588 (56.8) | 0.68 (0.56–0.81) | 0.90 (0.73–1.12) | 0.91 (0.74–1.13) | 0.91 (0.74–1.13) |
| Number of positive LN | |||||
| <6 | 2546 (64.0) | ref | ref | ref | |
| 6–11 | 467 (66.6) | 1.12 (0.91–1.38) | 1.09 (0.81–1.46) | 1.10 (0.82–1.48) | 1.08 (0.81–1.45) |
| ≥12 | 167 (62.9) | 0.95 (0.69–1.32) | 0.89 (0.58–1.37) | 0.88 (0.57–1.36) | 0.87 (0.57–1.35) |