Table 1.

Association results for the three previously identified BE risk SNPs 8 in 542 BE and 1106 EAC cases as well as 1602 controls of German descent

Phenotype	SNP	Chromosome	Position (bp)a	Alleleb	MAFc (%) in cases	MAFc (%) in controls	RRd (95% CI)	P value	Nearby genee
BE	rs3072	2p24	20,741,887	G/A	38.1	37.0	1.05 (0.91–1.21)	5.32 × 10−01	GDF7
BE	rs2701108	12q24	113,158,644	G/A	35.5	38.6	0.87 (0.75–1.01)	6.38 × 10−02	TBX5
BE	rs3784262	15q22	56,040,398	G/A	40.7	46.4	0.79 (0.68–0.91)	9.70 × 10−04	ALDH1A2
EAC	rs3072	2p24	20,741,887	G/A	41.3	37.0	1.20 (1.07–1.34)	1.48 × 10−03	GDF7
EAC	rs2701108	12q24	113,158,644	G/A	35.6	38.6	0.88 (0.78–0.98)	2.47 × 10−02	TBX5
EAC	rs3784262	15q22	56,040,398	G/A	44.3	46.4	0.92 (0.82–1.03)	1.30 × 10−01	ALDH1A2
BE/EAC	rs3072	2p24	20,741,887	G/A	40.3	37.0	1.15 (1.04–1.27)	7.53 × 10−03	GDF7
BE/EAC	rs2701108	12q24	113,158,644	G/A	35.6	38.6	0.88 (0.79–0.97)	1.12 × 10−02	TBX5
BE/EAC	rs3784262	15q22	56,040,398	G/A	43.1	46.4	0.88 (0.79–0.97)	8.06 × 10−03	ALDH1A2

^aChromosomal position according to hg18.

^bFirst allele represents the minor allele.

^cMinor allele frequency (MAF) is given for cases and controls.

^dRelative Risk (RR) with 95% Confidence Interval (CI) indicating the genetic effect size is given for the minor allele.

^eNearest gene to the associated SNPs is shown.