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. Author manuscript; available in PMC: 2016 May 12.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Feb 13;23(7):1929–1934. doi: 10.1016/j.bmcl.2013.02.015

Figure 2.

Figure 2

The mammalian circadian clock. (a) The mechanism of the mammalian molecular clock illustrating the feedback loop that maintains 24-h oscillations of BMAL1-CLOCK/NPAS2 and PER-CRY expression. (b) Illustration of antiphase circadian oscillations of BMAL1-CLOCK/NPAS2 and PER-CRY expression. (c) Schematic illustrating the relationship between the core clock and clock-controlled genes.