Table 2.
The significant connections returned from sscMap using the HDACi optimal gene signature (k=5) obtained from the “simulated experiment”
| Compound | Replicates | cscore | p value | zscore | SM | PS |
|---|---|---|---|---|---|---|
| Sodium phenylbutyrate | 7 | 0.684 | 5.0E-06 | 7.93 | 1 | 1 |
| Trichostatin A | 182 | 0.822 | 5.0E-06 | 6.18 | 1 | 1 |
| Scriptaid | 3 | 0.928 | 5.0E-06 | 5.39 | 1 | 1 |
| Valproic acid | 57 | 0.323 | 1.0E-05 | 5.31 | 1 | 1 |
| Rifabutin | 3 | 0.880 | 5.0E-06 | 5.21 | 1 | 1 |
| Vorinostat | 12 | 0.890 | 5.0E-06 | 5.19 | 1 | 1 |
| MS-275 | 2 | 0.954 | 5.0E-06 | 4.30 | 1 | 1 |
| Withaferin A | 4 | 0.729 | 2.0E-05 | 3.97 | 1 | 1 |
| HC toxin | 1 | 0.928 | 5.0E-06 | 3.59 | 1 | 1 |
| 2-deoxy-D-glucose | 1 | 0.902 | 1.0E-05 | 3.49 | 1 | 1 |
All 7 known HDAC inhibitors, including those not used in signature generation, were pulled out. SM (significance mark) =1 indicates that the connection p value is less than the preset threshold E fp/N sets=1/1309≈7.6×10−4; PS (perturbation stability) is also shown here