eTable 2.
Guidelines Provided to Physician Panel for the Determination of IgE-Mediated Food Allergy in a Birth Cohort
| Allergen | Highly probable | Likely | Unlikely |
|---|---|---|---|
| Milk | Specific IgE ≥15 IU/mLa AND a SPT ≥ negative control OR a convincing medical history AND SPT >3 mm OR specific IgE >0.1 IU/mL | Convincing medical history AND specific IgE ≥0.1 IU/mL | No, equivocal, or weak medical history AND specific IgE <2 OR SPT ≤3 mm |
| Egg | Specific IgE ≥7 IU/mLa AND a SPT ≥ negative control OR a convincing medical history AND SPT >3 mm OR specific IgE >0.1 IU/mL | Equivocal or weak medical history AND specific IgE ≥2 IU/mL <95% PD points OR SPT >4 mm | No, equivocal, or weak medical history AND specific IgE <2 OR SPT ≤3 mm |
| Peanut | Specific IgE ≥14 IU/mLa AND a SPT ≥ negative control AND a convincing history AND SPT >3 mm OR specific IgE >0.1 IU/mL | Equivocal or weak history AND specific IgE ≥2 IU/mL <95% PD points OR SPT >4 mm | No, equivocal, or weak history AND specific IgE <2 OR SPT ≤3 mm |
Abbreviations: PD, predictive decision; SPT, skin prick test.
a
Adapted from Adverse Reactions to Food Committee of American Academy of Allergy, Asthma & Immunology. Work Group Report: Oral Food Challenge Testing. J Allergy Clin Immunol. 2009; 123(6 suppl):S365–S383.