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Exendin-4 treatment suppresses cellular hypertrophic response in the infarcted myocardium. A: representative images of wheat germ agglutinin (WGA) staining showing sham, vehicle-treated MI, and exendin-4-treated MI in WT, Akt-1−/−, MKK3−/−, and Akt-1−/−;MKK3−/− mice. Scale bar = 80 μm. B–D: Quantitative analyses of myocyte cross-sectional area; values represent means ± SE (n = 3–5/per group), *P < 0.05 vs. sham. #P < 0.05 vs. MI + saline.
