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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Bioorg Med Chem. 2015 Jul 26;23(17):5483–5488. doi: 10.1016/j.bmc.2015.07.034

Figure 4. Inhibition of ULK1 in cells.

Figure 4

The ULK1 inhibitors were evaluated for inhibition of autophagy in cells, and then evaluated by Western blot. HeLa cells were treated with the indicated compounds for 24 hours at a concentration of 4 μM. The lysates were then immunoblotted for LC3 and actin (as a loading control). The compounds led to an accumulation of the LC3-I precursor, which suggests a blockage of autophagy.