. Author manuscript; available in PMC: 2016 Sep 1.

Published in final edited form as: Bioorg Med Chem. 2015 Jul 26;23(17):5483–5488. doi: 10.1016/j.bmc.2015.07.034

Table 1. Potencies of ULK1 inhibitors.

Compounds were tested against ULK1, ULK2 and PDK1 in an in vitro kinase assay. Assay was performed in duplicate.

Compound	ULK1 IC₅₀ (nM)	ULK2 IC₅₀ (nM)	PDK1 IC₅₀ (nM)
Compound 1	5.3 ± 0.91	13 ± 3.3	420 ± 43
BX-795	87 ± 7.4	310 ± 88	65 ± 3.9
Compound 2	67 ± 15	200 ± 49	56 ± 5.5
Compound 3	120 ± 1.7	360 ± 79	710 ± 270
MRT67307	170 ± 11	230 ± 21	421±19