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. 2016 May 12;11(5):e0155530. doi: 10.1371/journal.pone.0155530

Fig 2. Exploring disease mechanisms from a GO perspective.

Fig 2

(A) Using inferred GO-CC data, the number of diseases (red numbers) can be associated with cellular locations, providing an additional level of information for potential, druggable targets. Interactive cell maps can be annotated with these inferences to allow navigation and exploration. The 1,178 diseases mapping to the mitochondrion (boxed arrow) were clustered to MEDIC disease categories (pie chart), and the top four categories are highlighted: nervous system diseases (N), genetic inborn diseases (G), metabolic diseases (M), and cancers (C). (B) The inferred GO-MF terms (blue numbers) for six cancers (red circles) share a subset of 210 molecular functions (blue box), providing core molecular activities informing common mechanisms of cancer.