Fig 1. Circulating miRNA levels after oral and transdermal administration of T and during the control period.

Levels of miR-342 (A) and miR-150 (B) in plasma samples collected from healthy volunteers after administration of oral (gray line) or transdermal (dashed line) T or in the control phase (black line). Collection time points are indicated on the x-axis. Data were normalized against the corresponding levels of endogenous miR-486-5p. Values are expressed as means (±SE) of 19 independent samples. (*) indicates statistically significant difference relative to time = 0 h.