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. 2016 May 11;13:25. doi: 10.1186/s12989-016-0137-5

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© Nikota et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Enrichment analysis of the biological functions in the Th2 cluster involved the immune response. A short list of genes was generated for the Th2 response cluster (highlighted in blue in Fig. 1). Genes that were differentially expressed in at least 50 % of the arrays that make up the cluster were included in the shortlist. The ClueGO app for Cytoscape software with GO Fusion was utilized to identify biological functions that were enriched in the shortlist and reduce any repetitive GOs. GOs were further collapsed back to their parent GOs to further simplify data presentation. A heatmap was generated to visualize the cluster’s shortlist, organized by biological function