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. 2010 Mar 18;298(6):G994–G1003. doi: 10.1152/ajpgi.00517.2009

Fig. 6.

Fig. 6.

Strain increased Schlafen 3 protein and DPPIV activity on collagen but not on fibronectin. A: IEC-6 cells cultured on membranes coated with collagen or fibronectin were maintained under static conditions or repetitive deformation for 24 h before lysis and Western blot for Schlafen 3 protein. Schlafen 3 expression of IEC-6 cells was different in response to strain on collagen compared with cells on fibronectin. Induction of Schlafen 3 expression across collagen by strain was statistically significant. In contrast, little stimulation of Schlafen 3 expression by strain was observed in cells cultured on fibronectin (n = 4; *P < 0.05). B: DPPIV activity was determined by DPPIV activity assay in IEC-6 cells subjected to 24 h of strain after grown to confluence on either collagen or fibronectin. Fibronectin slightly decreased basal DPPIV activity and prevented any stimulation of DPPIV activity by strain in contrast to collagen (n = 5; *P < 0.01).