Table 1. Clinical features of patients and healthy controls.
| Characterizations and parameters | Inflamed CD n = 22 | Uninflamed CD n = 5 | Healthy control n = 6 |
|---|---|---|---|
| Age (years), median (range) | 32 (18–63) | 32 (22–46) | 49 (31–72) |
| Gender, number | |||
| Female | 13 | 2 | 2 |
| Male | 9 | 3 | 4 |
| Donated tissue location, number (biopsies/surgical resections) | |||
| Ileum | 7 (5/2) | 0 (0/0) | 0 (0/0) |
| Colon | 15 (9/6) | 5 (5/0) | 6 (6/0) |
| Disease phenotype, number (% of total) | |||
| Colonic (L2)* | 10 (45%) | ||
| Ileocolonic (L3)* | 7 (32%) | ||
| Ileal (L1)* | 5 (23%) | ||
| Medication up to 3 months prior, % of total | |||
| 5-ASA | 0 | 0 | 0 |
| Corticosteroids | 10 | 0 | 0 |
| Azathioprine/6-Mercaptopurine | 24 | 60 | 0 |
| Anti-TNF-α agents | 5 | 40 | 0 |
| Without medication | 61 | 20 | 100 |
| SES, mean (range) | 12 (2–28) | 1.2 (0–3) | 0 (0) |
| HB score, mean (range) | 6.4 (2–17) | 4.4 (1–6) | 0 (0) |
| CRP (mg/l), mean (range) | 44.2 (0.3–190) | 23.2 (1–83) | 3.5 (0.3–12) |
| Fecal calprotectin (mg/kg), mean (range) | 1719 (30–3600) | 497 (30–971) |
5-ASA, 5-aminosalicylic acid; TNF, tumor necrosis factor; SES, Standard Endoscopic Index; HB, Harvey Bradshaw; CRP, C-Reactive Protein (normal < 10 mg/l); Fecal calprotectin (normal < 30 mg/kg).
*Montreal Classification.