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. 2016 May 12;11(5):e0155338. doi: 10.1371/journal.pone.0155338

Fig 5. Schematic representation of artificial promoters and their expression in tumor environment.

Fig 5

Promoters were compiled by introduction of the respective elements taken from promoters P0.212, P1.6, P0.134 as well as consensus sequences into the template sequence. Additionally, regions around TSS were enriched for A/T to facilitate DNA melting. Expression values are relative to the expression of P0.212_1. Given are mean±SD. Only promoter P2.3 showed expression in tumor. No expression in tumor or spleen could be observed for the other promoters. Nucleotide sequences are presented in the S3 Fig. Foot note: I, II, III—corresponding sequences were taken from promoters P0.212, P1.6, P0.134 respectively. cons—consensus sequences for the corresponding elements. a, b—modification of loci around putative start of transcription to facilitate DNA melting by random substitution of "C/G"s by "A/T"s.