Table 4. Association of high-order gene-gene interactions with EC risk by MDR analysis.

Number of loci	Best interaction models	Testing accuracy	Cross-validation consistency	P for permutation test
1	TGFBR1 rs6478974 T>A	0.561	9/10	<0.05
2	TGFB1 rs1800469 C>T,	0.589	10/10	<0.05
	TGFBR1 rs6478974 T>A
3	TGFB1 rs1800469 C>T,	0.584	7/10	<0.05
	TGFBR1 rs6478974 T>A,
	TGFBR1 rs10733710 G>A
4	TGFB1 rs1800469 C>T,	0.575	6/10	<0.05
	TGFBR1 rs6478974 T>A,
	TGFBR1 rs10512263 T>C,
	TGFBR1 rs10733710 G>A

EC, endometrial cancer; MDR, multifactor dimensionality reduction; CVC, cross-validation consistency.

Bold numbers denote a statistical significance at 0.05 level.