Table 6. Stratified analysis between protective haplotype CACGA of TGFBR1 and EC risk by family history of cancer, BMI status and menarche-FFTP intervals.
| All | Menarche-FFTP intervalsa ≤ 11 years | Menarche-FFTP intervalsa ˃ 11 years | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases (%)/Controls (%) | aOR (95% CI)b | Pb | Cases (%)/Controls (%) | aOR (95% CI)b | Pb | Cases (%)/Controls (%) | aOR (95% CI)b | Pb | |
| All | |||||||||
| Other haplotypes | 858 (83.14)/1056 (74.68) | Reference | 477 (81.12)/695 (75.87) | Reference | 381 (85.81)/361 (72.49) | Reference | |||
| CACGA | 174 (16.86)/358 (25.32) | 0.66 (0.51–0.84) | 0.0008 | 111 (18.88)/221 (24.13) | 0.79 (0.58–1.08) | 0.1330 | 63 (14.19)/137 (27.51) | 0.49 (0.31–0.75) | 0.0012 |
| Family history of cancer (yes) | |||||||||
| Other haplotypes | 131 (79.88)/216 (75.00) | Reference | 59 (73.75)/107 (75.35) | Reference | 72 (85.71)/109 (74.66) | Reference | |||
| CACGA | 33 (20.12)/72 (25.00) | 0.88 (0.49–1.56) | 0.6573 | 21 (26.25)/35 (24.65) | 1.28 (0.58–2.84) | 0.5373 | 12 (14.29)/37 (25.34) | 0.70 (0.25–1.98) | 0.5065 |
| Family history of cancer (no) | |||||||||
| Other haplotypes | 727 (83.76)/840 (74.60) | Reference | 418 (82.28)/588 (75.97) | Reference | 309 (85.83)/252 (71.59) | Reference | |||
| CACGA | 141 (16.24)/286 (25.40) | 0.61 (0.46–0.81) | 0.0005 | 90 (17.72)/186 (24.03) | 0.73 (0.52–1.02) | 0.0662 | 51 (14.17)/100 (28.41) | 0.49 (0.30–0.80) | 0.0044 |
| BMI ˂24 | |||||||||
| Other haplotypes | 286 (83.14)/409 (74.91) | Reference | 179 (81.36)/252 (77.78) | Reference | 107 (86.29)/157 (70.72) | Reference | |||
| CACGA | 58 (16.86)/137 (25.09) | 0.62 (0.40–0.96) | 0.0323 | 41 (18.64)/72 (22.22) | 0.75 (0.43–1.31) | 0.3075 | 17 (13.71)/65 (29.28) | 0.39 (0.17–0.90) | 0.0275 |
| BMI ≥24 | |||||||||
| Other haplotypes | 572 (83.14)/647 (74.54) | Reference | 298 (80.98)/443 (74.83) | Reference | 274 (85.63)/204 (73.91) | Reference | |||
| CACGA | 116 (16.86)/221 (25.46) | 0.70 (0.51–0.96) | 0.0255 | 70 (19.02)/149 (25.17) | 0.79 (0.54–1.15) | 0.2227 | 46 (14.38)/72 (26.09) | 0.54 (0.32–0.93) | 0.0269 |
EC, endometrial cancer; BMI, body mass index; FFTP, first full term pregnancy; OR, odds ratios; CI, confidence intervals.
a Both parous and nulliparous women were included. This parameter was measured by age at FFTP minus age at menarche in all parous women, age at menopause minus age at menarche in postmenopausal nulliparous women, and age at EC diagnosed (case) or age at interview (control) minus age at menarche in premenopausal nulliparous women.
b Adjusted for BMI, age at menarche, age at primiparity, number of childbirth, menopause status and family history of cancer in first-degree relatives.
Bold numbers denote a statistical significance at 0.05 level.