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. 2016 May 12;11(5):e0155368. doi: 10.1371/journal.pone.0155368

Fig 2. Fn14 concentration is increased in NTN model of kidney injury.

Fig 2

(A) Increased concentration of Fn14 was detected in serum of mice injected with nephrotoxic serum (NTS) (vehicle vs NTS-**p = 0.006, Mann-Whitney test). Serum analysis was performed at the end of the study at 21 days. (B) Rapid increase in Fn14 concentration in urine (closed circles) apparent two days post NTS injection, was accompanied by development of proteinuria (closed triangles), and remained elevated through the duration of the study. (C) Urinary Fn14 strongly correlated with urinary albumin (r = 0.8803; p<0.0001, Spearman’s test) and urinary MCP-1 (r = 0.8978; p<0.0001, Spearman’s test), on day 7 of NTN induction.