Fig 6. Therapeutically administered 140csH1 improves outcome in mouse lung infection model with PJ-1324.

(A-B) 6 h or (C) 24 h after i.t. infection with 0.8–2.7x10⁶ CFU of PJ-1324 in 50 μL PBS, CD-1 mice were treated i.p. with 200 μg isotype IgG2a mAb (open circles) or 140csH1 (closed circles). 24 h after infection, (A.) lung and (B.) tail vein blood CFU were determined (dotted line = detection limit of 100 CFU/mL). Combined results of three independent experiments are shown. *, p<0.04, isotype vs. 140csH1 treated mice, unpaired t-test. (C) Mice were treated 24 h after infection with isotype (open circles; n = 12 total) or 140csH1 (closed circles; n = 13 total). Survival was followed for 15 days after infection. Combined results of two independent experiments are shown. **, p<0.004, isotype vs. 140csH1 survival curve, Mantel-Cox test.