Fig. 2.
Pretreatment of SNpc with 6-OHDA induces delayed gastric emptying. Summary curve showing the results of the [13C]-octanoic acid breath test obtained before (A and B) or 4 wk after either saline (control) or 6-OHDA microinjections in the SNpc (C and D; n = 8 in each group). In C and D, note the significant reduction and rightward shift of the change over baseline (DOB) curve as well as the rightward shift of the cumulative dose curve. Note also the significant delay in both tmax (62 ± 3.8 and 81 ± 3.0 min in control and 6-OHDA-treated rats; E) and t1/2 (87 ± 7.1 and 111 ± 4.3 min in control and 6-OHDA-treated rats; F). *P < 0.05 vs. control.