Table 1.
Number of myenteric neurons/field of view in the proximal gastrointestinal tract
Control | 6-OHDA | ||
---|---|---|---|
Esophagus | PGP9.5 neurons | 23 ± 2.9 | 28 ± 4.8 |
% ChAT-IR neurons | 44 ± 2.2 | 35 ± 3.1* | |
% NOS-IR neurons | 57 ± 2.5 | 69 ± 5.8* | |
Fundus | PGP9.5 neurons | 88 ± 12.4 | 86 ± 10.9 |
% ChAT-IR neurons | 58 ± 1.5 | 49 ± 1.2* | |
% NOS-IR neurons | 27 ± 2.2 | 33 ± 2.1* | |
Corpus | PGP9.5 neurons | 114 ± 7.2 | 136 ± 12.2 |
% ChAT-IR neurons | 56 ± 3.8 | 45 ± 3.1* | |
% NOS-IR neurons | 27 ± 0.3 | 33 ± 1.4* | |
Duodenum | PGP9.5 neurons | 150 ± 9.3 | 134 ± 8.4 |
% ChAT-IR neurons | 56 ± 3.9 | 46 ± 0.9* | |
% NOS-IR neurons | 26 ± 2.3 | 32 ± 1.7* |
Data are means ± SE.
P < 0.05 vs. control. 6-OHDA, 6-hydroxy-dopamine; PGP9.5, protein gene product; ChAT, choline acetyl transferase; IR, immunoreactive; NOS, nitric oxide synthase.