Table 2.
The LT–p53 interface residues. The amino acids involved in direct interaction between SV40 LT (left, column_ SV40) and p53 (right, column_ p53) are summarized. The corresponding homologous residues in JCV (column_ JCV) and TSV (column_ TSV) are also listed. Sequence variations among the three LTs are represented as following: no filling_ same as SV40 LT; light gray filled_ different amino acid with similar chemical properties; dark gray filled_ amino acid with different chemical properties.
| SV40 | JCV | TSV | p53 |
|---|---|---|---|
| D402 | D403 | D447 | R248, R280 |
| W581 | W582 | W626 | M246 |
| P584 | P585 | P629 | M243 |
| Y582 | F583 | Y627 | M246 |
| V585 | V586 | I630 | M246 |
| A586 | A587 | T631 | P177 |
| Q593 | H594 | K638 | R181 |
| V597 | V598 | K642 | H178 |
| E601 | E602 | D646 | N239 |
| D604 | D605 | C649 | R273 |
| L609 | M610 | H654 | M246 |
| Y612 | F613 | F657 | M246 |
| Q613 | S614 | A658 | N288 |