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. Author manuscript; available in PMC: 2016 May 12.
Published in final edited form as: Nat Rev Drug Discov. 2014 Mar;13(3):197–216. doi: 10.1038/nrd4100

Figure 1. Structure of the RORs and REV-ERBs.

Figure 1

a | The general organizational structure of members of the nuclear receptor superfamily. b | Structure of the REV-ERBs. c | Structure of the retinoic acid receptor-related orphan receptors (RORs). Numbers above each receptor represent the amino acid position. Percentages indicate amino acid identity within a particular domain relative to either REV-ERBα or RORα. A/B, C, D, E and F refer to classically defined regions in the nuclear receptor domain structure. DBD, DNA-binding domain; LBD, ligand-binding domain.