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. Author manuscript; available in PMC: 2016 May 12.
Published in final edited form as: Nat Rev Drug Discov. 2014 Mar;13(3):197–216. doi: 10.1038/nrd4100

Figure 6. ROR inverse agonists alter TH cell development.

Figure 6

T helper 1 (TH1), TH2, TH17 and regulatory T (TReg) cells develop from naive CD4+ TH cells. The differentiation of naive CD4+ TH cells into these effector CD4+ T cells is initiated via an interaction of dendritic cells with naive CD4+ TH cells. Effector cell types are defined by their production of specific cytokines, function, modulation of distinct signalling pathways and the expression of distinct transcription factors. Retinoic acid receptor-related orphan receptor (ROR) inverse agonists suppress TH17 cell differentiation and function. The RORγ inverse agonist SR1555 promotes TReg cell differentiation as well. ATRA, all-trans retinoic acid; FOXO3, forkhead box protein O3; GATA3, GATA-binding protein 3; IFNγ, interferon-γ; IL, interleukin; STAT, signal transducer and activator of transcription; TBX21, T-box protein 21 (T-bet); TGFβ1, transforming growth factor-β1.