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. Author manuscript; available in PMC: 2016 May 12.
Published in final edited form as: Nat Rev Drug Discov. 2014 Mar;13(3):197–216. doi: 10.1038/nrd4100

Table 1. Natural ligands of the nuclear receptors REV-ERB and ROR.

Ligands Structure or scaffold Receptor
(or receptors)		 Refs

  • Haem

 graphic file with name nihms-784148-t0008.jpg REV-ERBα,
REV-ERBβ		 17,84

  • Cholesterol

  • Cholesterol sulphate

 graphic file with name nihms-784148-t0009.jpg RORα 93

  • 7α-hydroxycholesterol

  • 7β-hydroxycholesterol

  • 7-ketocholesterol

 graphic file with name nihms-784148-t0010.jpg RORα, RORγ 96

  • 20α-hydroxycholesterol

  • 22R-hydroxycholesterol

  • 25-hydroxycholesterol

 graphic file with name nihms-784148-t0011.jpg RORα 97

  • 24S-hydroxycholesterol

  • 24R-hydroxycholesterol

  • 24,25-epoxycholesterol

 graphic file with name nihms-784148-t0012.jpg RORα, RORγ 96

  • Stearic acid

 graphic file with name nihms-784148-t0013.jpg RORβ 99

  • All-trans retinoic acid

 graphic file with name nihms-784148-t0014.jpg RORβ 98

  • Neoruscogenin

  • (25S)-ruscogenin

 graphic file with name nihms-784148-t0015.jpg RORα 99

ROR, retinoic acid receptor-related orphan receptor.