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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Hypertension. 2016 Apr 25;67(6):1281–1290. doi: 10.1161/HYPERTENSIONAHA.116.07548

Figure 1. Effect of androgen receptor antagonism on mean arterial pressure (MAP) and sex steroids in female intrauterine growth-restricted (IUGR) rats that develop an increase in blood pressure at 12 months of age.

Figure 1

Female control and intrauterine growth-restricted (IUGR) rats received vehicle or were treated for 2 weeks with the androgen receptor antagonist flutamide (8 mg · kg−1 · d−1; Vehicle-treated control n=11, Vehicle-treated IUGR n=12, flutamide-treated control n=9, flutamide-treated IUGR n=10). MAP was measured at 12 months of age in chronically instrumented, conscious animals via carotid catheter (Figure 1a). Circulating testosterone and estradiol levels were measured in control and IUGR offspring at 12 months of age (Figure 1b, 1c). *P<0.05 versus vehicle-treated control. †P<0.05 versus vehicle-treated IUGR. Data values represent mean±SEM.