Table 1.
EAE disease parameters
| Treatment group | Figure1 | Number of mice |
Peak disease score2 |
Disease score day 303 |
Cumulative disease score4 |
p value versus PBS5 |
|---|---|---|---|---|---|---|
| PBS6,8 | 1A | 5 | 2.0 ± 0 | 1.2 ± 0.1 | 23.5 ± 1 | |
| KYC 0.03 mg/kg6,8 | 1A | 5 | 2.0 ± 0 | 1.2 ± 0.2 | 22.8 ± 2 | 0.88 |
| KYC 0.3 mg/kg6,8 | 1A | 5 | 1.3 ± 0.1 | 0.7 ± 0.1 | 14 ± 1 | 0.008 |
| KYC 3 mg/kg6,8 | 1A | 5 | 1.2 ± 0.4 | 0.4 ± 0.2 | 10.4 ± 3 | 0.008 |
| PBS6,9 | 1B | 10 | 1.9 ± 0.2 | 1.6 ± 0.2 | 25.2 ± 2 | |
| KYC 3 mg/kg6,9 | 1B | 10 | 1.2 ± 0.2 | 0.8 ± 0.2 | 15.5 ± 2 | 0.006 |
| PBS6,10 | 1C | 5 | 2.4 ± 0.2 | 1.8 ± 0.2 | 29.3 ± 4 | |
| KYC 3 mg/kg6,10 | 1C | 9 | 1.8 ± 0.2 | 0.7 ± 0.1 | 16.3 ± 2 | 0.03 |
| PBS7,8 | 1D | 10 | 1.5 ± 0.5 | 0.1 ± 0.07 | 10.7 ± 1.4 | |
| KYC 3 mg/kg7,8 | 1D | 10 | 0.85 ± 0.1 | 0 ± 0 | 3.6 ± 1 | 0.0004 |
| PBS7,11 | 1E | 9 | 2.4 ± 0.1 | 0.67 ± 0.1 | 21.1 ± 1 | |
| KYC 3 mg/kg7,11 | 1E | 10 | 2.1 ± 0.07 | 0.28 ± 0.09 | 11.9 ± 0.9 | 0.0004 |
Designates the EAE graph from which the data were generated.
Peak disease score data are the mean ± SE.
Day 30 disease score data are the mean ± SE.
The cumulative disease score was calculated by adding the daily disease score from day 0 for Fig. 1A and 1D, from day 10 for Fig. 1B, from day 17 for Fig. 1C and from day 15 for Fig. 1E. Data are the mean ± SE.
The p value was calculated by Mann-Whitney test comparing the KYC treated group versus PBS for the cumulative disease score.
EAE was induced in C57BL/6 mice by immunization with MOG35–55.
EAE was induced in B10.PL mice by the adoptive transfer of 1 × 106 MBP-specific encephalitogenic T cells.
Mice were i.p. administered PBS or KYC starting on day 0.
Mice were i.p. administered PBS or KYC starting on day 10.
Mice were i.p. administered PBS or KYC starting on day 17.
Mice were i.p. administered PBS or KYC starting on day 15.