Association between the prevalence, treatment and control of hypertension and the prevalence of MCI in participants without cerebrovascular disease by gender (n=1804).
| Prevalence of MCI | N (%) | Unadjusted OR (95% CI), P | Adjusteda OR (95% CI), P |
| Male | |||
| Normotensives (reference group) | 32/275 (11.6) | ||
| Hypertensives | 74/447 (16.6) | 1.51 (0.97–2.35), 0.071 | 2.22 (1.15–4.29), 0.017 |
| Untreated hypertensives (reference group) | 35/174 (20.1) | ||
| Treated hypertensives | 39/273 (14.3) | 0.66 (0.40–1.09), 0.107 | 0.60 (0.31–1.14), 0.118 |
| Uncontrolled hypertensives among hypertensives (reference group) | 60/320 (18.8) | ||
| Controlled hypertensives among hypertensives | 14/127 (11.0) | 0.54 (0.29–1.00), 0.050 | 0.57 (0.27–1.19), 0.134 |
| Uncontrolled hypertensives among treated hypertensives (reference group) | 25/146 (17.1) | ||
| Controlled hypertensives among treated hypertensives | 14/127 (11.0) | 0.60 (0.30–1.21), 0.154 | 0.68 (0.30–1.58), 0.375 |
| Female | |||
| Normotensives (reference group) | 43/331 (13.0) | ||
| Hypertensives | 115/751 (15.3) | 1.21 (0.83–1.77), 0.319 | 1.30 (0.73–2.33), 0.371 |
| Untreated hypertensives (reference group) | 43/241 (17.8) | ||
| Treated hypertensives | 72/510 (14.1) | 0.76 (0.50–1.14), 0.187 | 0.72 (0.43–1.21), 0.220 |
| Uncontrolled hypertensives among hypertensives (reference group) | 86/538 (16.0) | ||
| Controlled hypertensives among hypertensives | 29/213 (13.6) | 0.83 (0.53–1.31), 0.417 | 0.85 (0.50–1.44), 0.534 |
| Uncontrolled hypertensives among treated hypertensives (reference group) | 43/297 (14.5) | ||
| Controlled hypertensives among treated hypertensives | 29/213 (13.6) | 0.93 (0.56–1.55), 0.783 | 0.88 (0.48–1.61), 0.681 |
| All | |||
| Normotensives (reference group) | 75/606 (12.4) | ||
| Hypertensives | 189/1198 (15.8) | 1.33 (1.00–1.77), 0.054 | 1.61 (1.05–2.48), 0.029 |
| Untreated hypertensives (reference group) | 78/415 (18.8) | ||
| Treated hypertensives | 111/783 (14.2) | 0.71 (0.52–0.98), 0.037 | 0.67 (0.45–0.99), 0.045 |
| Uncontrolled hypertensives among hypertensives (reference group) | 146/858 (17.0) | ||
| Controlled hypertensives among hypertensives | 43/340 (12.6) | 0.71 (0.49–1.02), 0.062 | 0.72 (0.47–1.10), 0.130 |
| Uncontrolled hypertensives among treated hypertensives (reference group) | 68/443 (15.3) | ||
| Controlled hypertensives among treated hypertensives | 43/340 (12.6) | 0.80 (0.53–1.20), 0.283 | 0.81 (0.50–1.31), 0.390 |
Abbreviations: CI, confidence interval; MCI, mild cognitive impairment; OR, odds ratio.
a
Adjusted for age, education level, marital status, physical activity, smoking and drinking status, body mass index, triglycerides, high-density lipoprotein, low-density lipoprotein, diabetes mellitus (yes/no), history of stroke and family history of dementia.