Table 4. Determinants for the antihypertensive effect of olmesartan on morning home systolic blood pressure (BP) and clinic BPa.
|
Morning home systolic BP at baseline |
Clinic systolic BP at baseline |
|||||||
|---|---|---|---|---|---|---|---|---|
| 140 mm Hg | 160 mm Hg | 180 mm Hg | Interaction Pb | 140 mm Hg | 160 mm Hg | 180 mm Hg | Interaction Pb | |
| Sex | <0.001* | |||||||
| Male | –8.4 (–33.1 to 16.3) | –22.8 (–47.5 to 1.9) | –37.1 (–61.8 to –12.4) | |||||
| Female | –9.2 (–34.9 to 16.5) | –24.5 (–50.2 to 1.2) | –39.9 (–65.6 to –14.2) | |||||
| Difference | –0.7 | –1.8 | –2.8 | NS | ||||
| Age | 0.022* | |||||||
| ⩾65 years | −8.0 (−36.8 to 20.9) | −22.4 (−51.3 to 6.4) | −36.9 (−65.8 to −8.1) | |||||
| <65 years | −9.4 (−37.1 to 18.3) | −24.3 (−52.1 to 3.4) | −39.3 (−67.0 to −11.5) | |||||
| Difference | NS | −1.5 | −1.9 | −2.4 | ||||
| History of cardiac disease | 0.002* | |||||||
| No | −7.9 (−36.2 to 20.3) | −22.7 (−50.9 to 5.6) | −37.4 (−65.7 to −9.2) | |||||
| Yes | −7.6 (−37.8 to 22.7) | −20.7 (−50.9 to 9.6) | −33.7 (−64.1 to −3.4) | |||||
| Difference | NS | 0.4 | 2.0 | 3.7 | ||||
| Alcohol drinking habit | 0.082 | |||||||
| Not daily | –9.4 (–34.7 to 15.9) | –24.4 (–49.7 to 0.9) | –39.4 (–64.7 to –14.1) | |||||
| Daily | –9.3 (–34.2 to 15.7) | –23.7 (–48.6 to 1.2) | –38.1 (–63.1 to –13.2) | |||||
| Difference | 0.1 | 0.7 | 1.3 | NS | ||||
| Comorbidity of diabetes mellitus | <0.001* | <0.001* | ||||||
| No | –9.4 (–34.3 to 15.5) | –24.5 (–49.4 to 0.4) | –39.6 (–64.5 to –14.7) | −7.6 (−35.4 to 20.2) | −22.5 (−50.3 to 5.2) | −37.5 (−65.2 to −9.7) | ||
| Yes | –7.9 (–34.3 to 18.6) | –21.9 (–48.3 to 4.6) | –35.9 (–62.4 to –9.4) | −6.8 (−37.2 to 23.6) | −20.4 (−50.8 to 10.0) | −34.1 (−64.5 to −3.7) | ||
| Difference | 1.5 | 2.6 | 3.7 | 0.8 | 2.1 | 3.4 | ||
| Comorbidity of dyslipidemia | 0.023* | |||||||
| No | −7.7 (−35.8 to 20.4) | −22.6 (−50.7 to 5.5) | −37.5 (−65.6 to −9.4) | |||||
| Yes | −8.3 (−37.0 to 20.3) | −22.7 (−51.4 to 5.9) | −37.1 (−65.8 to −8.5) | |||||
| Difference | NS | −0.6 | −0.1 | 0.4 | ||||
| Comorbidity of hepatic disease | 0.043* | |||||||
| No | –9.4 (–34.6 to 15.7) | –24.4 (–49.6 to 0.8) | –39.3 (–64.5 to –14.2) | |||||
| Yes | –9.7 (–35.5 to 16.1) | –23.7 (–49.5 to 2.2) | –37.7 (–63.5 to –11.8) | |||||
| Difference | −0.2 | 0.7 | 1.7 | NS | ||||
Abbreviation: NS, not significant.
a
Data expressed as predictive value (95% prediction interval). *P<0.05.
b
Interaction P-values are for the interaction term between each factor and baseline systolic BP using a multiple regression model for morning home systolic BP (left) or clinic systolic BP (right).