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. 2015 Aug 17;35(18):2357–2369. doi: 10.1038/onc.2015.296

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ZNF322A overexpression accelerates tumor growth in vivo. (a–d) H460-Luc cells transfected with empty vector (Ctrl) or ZNF322A expression vector (over-ZNF) were subcutaneously injected into severe combined immunodeficient mice. Luciferase intensity of tumor images (a) and quantitative IVIS intensity (b) were obtained on indicated days. Xenograft images (c) and quantitative weight (d) of tumor taken from mice on day 18 are shown. (e) Xenografts were subjected to tissue-immunoblotting to examine expression level of the indicated proteins. (f–i) Control (Ctrl) or ZNF322A knockdown A549-Luc cells were subcutaneously injected into BALB/c nude mice. Luciferase intensity of tumor images (f) and quantitative IVIS intensity (g) were obtained on indicated days. Xenograft images (h) and quantitative weight (i) of tumor taken from mice at day 28 are shown. (j) Xenografts were subjected to immunohistochemistry to examine expression of the indicated proteins. Data are mean±s.e.m. (n=5 mice per group). *P<0.05; **P<0.01.