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. 2015 Aug 17;35(18):2357–2369. doi: 10.1038/onc.2015.296

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Copyright © 2016 Macmillan Publishers Limited

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ZNF322A modulates the chromatin structure of ADD1, CCND1 and p53 promoter regions. (a) Promoter map for ADD1, CCND1 and p53 genes. (b and c) A549 cells transfected with ZNF322A expression vector (over-ZNF) (b) or si-ZNF322A oligo (si-ZNF) (c) were subjected to ChIP–qPCR analyzes for acetylated histone 3 (H3ac) open chromatin mark. (d) A549 cells transfected with si-ZNF oligo were subjected to ChIP–qPCR analysis for histone deacetylase 3 (HDAC3) repressive protein. Data are mean±s.e.m. (n=3). *P<0.05; ***P<0.001. (e) Schematic representation of transcriptional induction of ZNF322A at ADD1 and CCND1 and repression at p53, and subsequent promotion of cell proliferation, tumor metastasis and poor prognosis.