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Mechanisms of CTL-mediated cytotoxicity. Various pathways, including perforin/granzyme, Fas/Fas ligand, membrane-bound TNF-α, membrane-bound lymphotoxin, and TRAIL, underlie CTL-mediated cytotoxicity. Among these, granule exocytosis that is mediated by the perforin/granzyme and Fas/Fas ligand pathways are believed to be the main mechanisms of CTL-mediated antigen-specific cytotoxicity.
