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. 2016 May 13;4:47. doi: 10.3389/fped.2016.00047

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Copyright © 2016 Ishii.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Secretion of lytic granules in NK/CTL. After stimulating target cells, CTL organizes the immunological synapse. Rab27a promotes the transporting and docking of lytic granules at the immunological synapse along with Munc13-4. Interactions between Munc18-2 and SNARE (such as syntaxin 11) allow lytic granules to reach the synapse, where granule secretion occurs.