Table 2.
Neuropsychology results of FAD gene carriers and age-matched controls. Mean values are given with SDs.
| Test | Controls (N = 50) | Asymptomatic carriers (N = 12) | p Value or C.I. estimates by boot strapping |
|---|---|---|---|
| IQ (WASI) | 116.9 (11.9) | 103.6 (13.2) | <.001 |
| RMT Words/50 | 48.4 (2.2) | 47 (2.6) | −3.1 to .2 |
| RMT Faces/50 | 41.6 (4.9) | 43.3 (3.4) | .21 |
| WMS-LM immediate/25 | 16.4 (4.2) | 14.3 (3.8) | .10 |
| WMS-LM delayed/25 | 14.9 (3.9) | 13.5 (3.3) | .25 |
| Rey (delay:copy) | .69 (.1) | .61 (.2) | .11 |
| Digit span forward max/8 | 7.2 (1.1) | 6.9 (1.0) | −.34 to .09 |
| Digit span backward max/7 | 5.31 (1.2)) | 5.42 (1.0) | .36 |
| Spatial span forward max/9 | 5.9 (1.0) | 5.3 (1.2) | −1.5 to .04 |
| Spatial span backward max/9 | 5.5 (1.0) | 5.4 (1.2) | .96 |
| Letter fluency (FAS) | 46.7 (11.0) | 43.8 (5.8) | .57 |
| Stroop | 28.1 (10.4) | 32.8 (10.2) | .22 |
| Trail making | 30.7 (20.5) | 34.4 (14.8) | −8.6 to 13.2 |
| Category fluency | 39.4 (8.3) | 38.4 (11.7) | .94 |
| GNT/30 | 20.7 (4.7) | 19.6 (4.5) | .85 |
| GDA/24 | 16.2 (5.3) | 15.6 (4.3) | .9 |
| VOSP (object decision)/20 | 17.7 (1.7) | 18.4 (1.3) | .13 |
| Digit symbol | 39.4 (8.3) | 38.4 (11.7) | .18 |
| Test | Controls (N = 28) | Symptomatic carriers (N = 8) | p Value or C.I. estimates by boot strapping |
|---|---|---|---|
| IQ (WASI) | 116.7 (11.1) | 89.4 (21.6) | <.001 |
| RMT words/50 | 48 (1.9) | 38 (8.5) | −10.4 to −7.1 |
| RMT faces/50 | 42.6 (4.2) | 40.3 (3.7) | .40 |
| WMS-LM immediate/25 | 15.1 (3.8) | 8.4 (3.7) | .01 |
| WMS-LM delayed/25 | 14.5 (3.5) | 5.5 (3.6) | <.001 |
| Rey (delay:copy) | .67 (.14) | .36 (.22) | <.001 |
| Digit span forward max/8 | 7.0 (1.1) | 5.9 (1.6) | .15 |
| Digit span backward max/7 | 5.1 (1.2) | 4.3 (1.6) | .005 |
| Spatial span forward maxa/9 | 5.5 (.7) | 4.3 (1.1) | .003 |
| Spatial span backward max/9 | 5.1 (.8) | 4.7 (1.1) | .19 |
| Letter fluency (FAS) | 46.4 (11.2) | 35.1 (11.1) | .051 |
| Stroop | 28.7 (11.6) | 56.9 (43.3) | .02 |
| Trail making | 35.2 (23.6) | 89.1 (75.8) | 13.9 to 95.2 |
| Category fluency | 39.3 (8.3) | 31 (7.3) | .053 |
| GNT/30 | 22.4 (4.7) | 18.4 (7.2) | .35 |
| GDA/24 | 16.4 (4.5) | 9.5 (5.9) | .003 |
| VOSP (object decision)/20 | 18.1 (2.0) | 17.8 (1.7) | .86 |
| Digit symbol | 56.6 (8.9) | 38.6 (14.5) | .001 |
RMT: recognition memory test.
WMS-LM: Wechsler Memory Scale-logical memory.
GNT: Graded naming test.
GDA: Graded difficulty arithmetic test.
VOSP: Visual Object and Spatial Perception.
a
Scores from spatial span forward maximum underwent cube transformation.