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. 2016 May 13;10:127. doi: 10.3389/fncel.2016.00127

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Copyright © 2016 Zhuo, Peng, Liu, Yan, Xu, Zheng, Wei and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of incorporation of ΔpCt or ΔCt on the gating processes induced by 2-APB. (A) Diagram of a single TREK-2 subunit, transmembrane segments 1~4 (M1~M4), N-terminus, the proximal C-terminus (pCt), pore domain 1 (P1) and 2 (P2), glycine hinge of M2 (G196) and M4 (G312) are indicated. (B) Exemplar current-voltage recordings from oocytes expressing the indicated channels in the presence of 100 μM 2-APB. (C,D) Comparative analysis of the 2-APB evoked activation curves for the indicated channels. Due to the lower sensitivity of ΔpCt-ΔpCt to 2-APB, higher concentrations were used in its curve.