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. 2016 May 13;10:127. doi: 10.3389/fncel.2016.00127

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Copyright © 2016 Zhuo, Peng, Liu, Yan, Xu, Zheng, Wei and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of incorporation of G312A on the gating processes induced by 2-APB and extracellular alkalization. (A) Exemplar current-voltage recordings from oocytes expressing the indicated channels in the presence of 100 μM 2-APB. (B) Concentration responses of indicated channels activated by 2-APB. (C) Exemplar current-voltage recordings from oocytes expressing the indicated channels as pH_o transitions among 6.5, 8.0 and 9.3. (D) Comparative analysis of pH_o-inhibition curves for the indicated channels.